A new formula, now with Sumalate® and Quatrefolic® for enhanced bioavailability.

Chromagen contains Quatrefolic®, the bioactive form of folate1-3 

  • Quatrefolic® is a body ready form of folate that avoids the need for metabolic conversion to the active form
    • Bypasses the 4-step folic acid to 5–MTHF conversion process, and does not require the MTHFR enzyme
  • Quatrefolic® ((6S)-5 methyltetrahydrofolate glucosamine salt) is almost 7X more bioavailable than folic acid at peak
  • Does not mask the signs or symptoms of vitamin B12 deficiency anemia

Active folate is required for many physiological functions4,5

  • Essential for DNA and RNA synthesis, amino acid metabolism, and homocysteine remethylation
  • No tolerable upper limit
  • Bioavailable Quatrefolic® allows signs and symptoms of vitamin B12 deficiency to be observed while aiding in red blood cell synthesis and development
  • Two iron supplementation for optimal absorption
  • Risk factors for marginal folate status or folate inadequacy include:
Unbalanced diets Alcohol consumption Malabsorptive conditions MTHFR mutations
 “low carb,” “low gluten,” corn masa-based, and limited vegetables reduce folate intake impedes folate absorption and metabolism, and speeds its breakdown celiac disease, gluten sensitivity, and inflammatory bowel disease can reduce folate absorption  polymorphisms impair folic acid metabolism

Two iron supplementation for optimal absorption

  • Highly bioavailable, chelated Sumalate® iron partnered with ferrous fumarate7-11
  • Proximal and distal absorption to offer complimentary action for optimal combined iron absorption12,13
  • Ascorbic acid (vitamin C) in Chromagen helps convert the unusable ferric form of iron into the usable ferrous form in the duodenum allowing for greater absorption8
  • Aspartic acid and glycine in Sumalate® are among the most absorbable amino acids and help with iron transport into the duodenum8


*Sumalate® (ferrous asparto glycinate) provides 40% absorption